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Langerhans cell histiocytosis rash

Langerhans cell histiocytosis rash

•PLCH (LCH in the Lungs)• Histiocytosis in the lungs primarily affects adult smokers. (95%) (Merck Manuals says "the disease occurs almost exclusively in whites 20 to 40 yr of age who smoke.") Three percent are non-smoking adults and the remaining 2% are children. According to the Histiocytosis Association, it is estimated that 63% of adults with LCH have lung involvement only. Symptoms of lung involvement include chest pain, shortness of breath,collapsed lung, dry cough, weight loss, f

•PLCH (LCH in the Lungs)• Histiocytosis in the lungs primarily affects adult smokers. (95%) (Merck Manuals says "the disease occurs almost exclusively in whites 20 to 40 yr of age who smoke.") Three percent are non-smoking adults and the remaining 2% are children. According to the Histiocytosis Association, it is estimated that 63% of adults with LCH have lung involvement only. Symptoms of lung involvement include chest pain, shortness of breath,collapsed lung, dry cough, weight loss, f

•LCH of the skin• When Histio affects the skin, it can present in any number of ways, making it easy to miss. The only way to definitively diagnose is through a skin biopsy. (Biopsy results can be affected, however, by use of topical steroids, and result in an incorrect negative.) Scaly, waxy rash or lesions, cradle cap, hair loss, diaper rash, dry patches, "eczema" ... any of these things (and more) that won't go away or frequently come and go should be biopsied to (hopefully) rule out LCH.

•LCH of the skin• When Histio affects the skin, it can present in any number of ways, making it easy to miss. The only way to definitively diagnose is through a skin biopsy. (Biopsy results can be affected, however, by use of topical steroids, and result in an incorrect negative.) Scaly, waxy rash or lesions, cradle cap, hair loss, diaper rash, dry patches, "eczema" ... any of these things (and more) that won't go away or frequently come and go should be biopsied to (hopefully) rule out LCH.

•LCH of the Liver• When LCH affects the liver, it can be deadly. This is what's referred to as "high risk organ involvement". The cells attack the liver causing scarring (sclerosis/fibrosis). This can lead to strictures (narrowing) in the bile ducts, which in turn slows the flow of bile through the liver. Slowing the bile can cause stones to develop, blocking bile flow entirely. This, then, leads to further damage to the liver. This is the same damage caused by a disease called Primary…

•LCH of the Liver• When LCH affects the liver, it can be deadly. This is what's referred to as "high risk organ involvement". The cells attack the liver causing scarring (sclerosis/fibrosis). This can lead to strictures (narrowing) in the bile ducts, which in turn slows the flow of bile through the liver. Slowing the bile can cause stones to develop, blocking bile flow entirely. This, then, leads to further damage to the liver. This is the same damage caused by a disease called Primary…

•LCH of the Bones• Bone lesions are generally discovered after X-rays done because of unexplained pain, redness, and/or swelling in an area. Depending on bone(s) affected, patients can also present with headaches, difficulty walking, or back/neck pain. As with skin involvement, bone lesions can be a single lesion in a single site, multiple lesions on one bone, or spread out throughout the body. The lesions tend to have well-defined edges on imaging. Biopsy can be done to get a definitive…

•LCH of the Bones• Bone lesions are generally discovered after X-rays done because of unexplained pain, redness, and/or swelling in an area. Depending on bone(s) affected, patients can also present with headaches, difficulty walking, or back/neck pain. As with skin involvement, bone lesions can be a single lesion in a single site, multiple lesions on one bone, or spread out throughout the body. The lesions tend to have well-defined edges on imaging. Biopsy can be done to get a definitive…

With lung cancer claiming top spot on the list of causes of cancer deaths, the advancements regarding specialized drugs, like Dabrafenib, to treat the variety of cases is essential. Roughly 2% of the patient population diagnosed with non-small cell lung cancer has the BRAF V600E mutation. - See more at: http://www.lgmpharma.com/blog/dabrafenib-named-breakthrough-therapy-lung-cancer/#sthash.XiZLX2Bw.dpuf

FDA declared a Breakthrough Therapy designation for Dabrafenib to treat metastatic BRAF mutation-positive non-small cell lung cancer.

Schematic representation of histiocyte developmental pathway.

Schematic representation of histiocyte developmental pathway.

A rare abscess-like presentation of Langerhans cell histiocytosis (PMID: 28418153 DOI: 10.1111/bjd.15327 )

A rare abscess-like presentation of Langerhans cell histiocytosis (PMID: 28418153 DOI: )

Langerhans Cell Histiocytosis (LCH)     Adult Langerhans Cell Histiocytosis As a Diagnostic Pitfall.  J Clin Oncol.  2014 Jun 23. pii: JCO.2...

Langerhans Cell Histiocytosis (LCH) Adult Langerhans Cell Histiocytosis As a Diagnostic Pitfall. J Clin Oncol.