Multiple myeloma is a cancer of your plasma cells, a type of white blood cell present in your bone marrow. Plasma cells normally make proteins calledantibodies to help you fight infections. In multiple myeloma, a group of plasma cells (myeloma cells) becomes cancerous and multiplies, raising the number of plasma cells to a higher than normal level. Since these cells normally make proteins (antibodies), the level of abnormal proteins in your blood also may go up.
[ACUTE MYELOGENOUS LEUKEMIA, M0, BLOOD]. A myeloblast of an AML-M0 is compared to a medium-sized normal lymphocyte. Note the presence of only very scant cytoplasm in a blast and finer evenly-distributed chromatin in comparison to a lymphocyte. The high nuclear to cytoplasmic ration (N/C ratio) is a common albeit not a required feature of blasts. The single defining morphologic feature of a blast is it’s finely distributed nuclear chromatin.