Myasthenia Gravis: Facts, Symptoms, Treatments | Canadian Pharmacy Meds
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Myasthenia Gravis. Myasthenia gravis (MG) was first described by Thomas Willis in 1672. It is an acquired autoimmune disease with antibodies against the nicotinic acetylcholine receptor (AChR) at the neuromuscular junction or muscle-specific tyrosine kinase (MuSK). This leads to muscular weakness with easy 'fatiguability', which is worse on exercise and improves with rest. (read more here)
The easy explanation to why it's difficult for people with myasthenia gravis to exercise!
Autoimmune destruction of Ach receptors Proximal muscle weakness, ptosis, diplopia Sx ↑ with activity Myasthenic crisis: acute respiratory compromise Ice test: ↓ sx Edrophonium: ↓ sx in myasthenic crisis and ↑ sx in cholinergic crisis