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Using functional magnetic resonance imaging, researchers have found brain changes in preschool-age children with depression that are not apparent in their nondepressed peers.The children underwent M.R.I. brain scans while viewing pictures of happy, sad, fearful or neutral faces. The researchers found that right amygdala and right thalamus activity was significantly greater in the depressed children than in the others, a finding that has also been observed in depressed adolescents and adults.

Your brain on depression~ PET scan shows hot spots of increased activity in the brain of a non-depressed person. (Depression is not a sign of weakness or negative personality. It is a major health problem and a treatable medical condition)