Rodan+Fields Macro E vs Clarisonic,,,What's the difference? The clarisonic brush you use every night with a cleanser and it uses sonic frequency to remove 6X more makeup and 2X more dirt and oil than cleansing with your hands alone. The MACRO E is used only once a week with no cleanser and it removes the top layer of dead skin. Over 5,000,000 "MILLION" dead skin cells in just one pass! Making your skin more luminous and bright! :) Hallelujah!!!